Hypotensive activity of fibroblast growth factor.

  title={Hypotensive activity of fibroblast growth factor.},
  author={Pedro Cuevas and Fernando Carceller and Sara Barrera Ortega and Mercedes Zazo and Iris Nieto and Guillermo Gim{\'e}nez-Gallego},
  volume={254 5035},
Acidic and basic fibroblast growth factors (FGFs) are members of a family of proteins that are broad-spectrum mitogens, have diverse hormone-like activities, and function in tumorigenesis. FGF's ability to raise the concentration of intracellular calcium ion suggests that FGF could induce the synthesis of endothelium-derived relaxing factor (EDRF) and consequently vasodilation. Systemic administration of FGF decreased arterial blood pressure. This effect was mediated by EDRF and by adenosine… CONTINUE READING


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