Hypotension with intravenous immunoglobulin therapy: importance of pH and dimer formation.

@article{Kroez2003HypotensionWI,
  title={Hypotension with intravenous immunoglobulin therapy: importance of pH and dimer formation.},
  author={Monika Kroez and Ernst J{\"u}rgen Kanzy and Peter Gronski and Gerhard Dickneite},
  journal={Biologicals : journal of the International Association of Biological Standardization},
  year={2003},
  volume={31 4},
  pages={277-86}
}
Therapy with intravenous immunoglobulin preparations has been used effectively in a wide range of conditions. Although generally well tolerated, intravenous immunoglobulin preparations may be associated with transient hypotension in some patients. This study examined the role of different immunoglobulin G fractions in the development of intravenous immunoglobulin-induced hypotension in an anaesthetized rat model and assessed the effects of a new liquid immunoglobulin prepared at a low pH on… CONTINUE READING
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