Hypotension and resistance to lipopolysaccharide-induced shock in transgenic mice overexpressing adrenomedullin in their vasculature.

@article{Shindo2000HypotensionAR,
  title={Hypotension and resistance to lipopolysaccharide-induced shock in transgenic mice overexpressing adrenomedullin in their vasculature.},
  author={Takero Shindo and Hiroko Kurihara and Koji Maemura and Yukiko Kurihara and Tomoyuki Kuwaki and Taro Izumida and Naoto Minamino and Ki Hwan Ju and Hideaki Morita and Yoshio Oh-hashi and Mamoru Kumada and Kenji Kangawa and Ryozo Nagai and Yoshikazu Yazaki},
  journal={Circulation},
  year={2000},
  volume={101 19},
  pages={2309-16}
}
BACKGROUND Adrenomedullin (AM) is a vasodilating peptide involved in the regulation of circulatory homeostasis and in the pathophysiology of certain cardiovascular diseases. To determine the extent to which chronic AM overproduction affects circulatory physiology under normal and pathological conditions, we used a preproendothelin-1 promoter to establish transgenic mouse lines overexpressing AM in their vasculature. METHODS AND RESULTS Transgenic mice overexpressing AM mainly in vascular… CONTINUE READING