Hypotension After Cardiac Operations Based on Autoregulation Monitoring Leads to Brain Cellular Injury.

@article{Hori2015HypotensionAC,
  title={Hypotension After Cardiac Operations Based on Autoregulation Monitoring Leads to Brain Cellular Injury.},
  author={Daijiro Hori and Masahiro Ono and Thomas E Rappold and John V. Conte and Ashish S Shah and Duke E. Cameron and Hideo Adachi and Allen Dale Everett and Charles W. Hogue},
  journal={The Annals of thoracic surgery},
  year={2015},
  volume={100 2},
  pages={487-93}
}
BACKGROUND Individualizing blood pressure targets could improve organ perfusion compared with current practices. In this study we assess whether hypotension defined by cerebral autoregulation monitoring vs standard definitions is associated with elevation in the brain-specific injury biomarker glial fibrillary acidic protein plasma levels (GFAP). METHODS Plasma GFAP levels were measured in 121 patients undergoing cardiac operations after anesthesia induction, at the conclusion of the… CONTINUE READING
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