Hypotension, autonomic failure, and cardiac hypertrophy in transgenic mice overexpressing the alpha 1B-adrenergic receptor.

@article{Zuscik2001HypotensionAF,
  title={Hypotension, autonomic failure, and cardiac hypertrophy in transgenic mice overexpressing the alpha 1B-adrenergic receptor.},
  author={Micheal J Zuscik and Dan Chalothorn and David Hellard and Clare Deighan and Ann McGee and Craig Michael Daly and David J. J. Waugh and Shelley A Ross and Robert J. Gaivin and Annitta J Morehead and Joanne D Thomas and Edward F Plow and John C. McGrath and Michael T. Piascik and Dianne Perez},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 17},
  pages={13738-43}
}
alpha(1)-Adrenergic receptors (alpha(1A), alpha(1B), and alpha(1D)) are regulators of systemic arterial blood pressure and blood flow. Whereas vasoconstrictory action of the alpha(1A) and alpha(1D) subtypes is thought to be mainly responsible for this activity, the role of the alpha(1B)-adrenergic receptor (alpha(1B)AR) in this process is controversial. We have generated transgenic mice that overexpress either wild type or constitutively active alpha(1B)ARs. Transgenic expression was under the… CONTINUE READING

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