Hyporesponsiveness in contact hypersensitivity and irritant contact dermatitis in CD4 gene targeted mouse.

@article{Kondo1996HyporesponsivenessIC,
  title={Hyporesponsiveness in contact hypersensitivity and irritant contact dermatitis in CD4 gene targeted mouse.},
  author={Satoko Kondo and Stefan Beissert and Binghe Wang and Hiroshi Fujisawa and Fatemeh Kooshesh and Alexander J. Stratigos and Richard D Granstein and Tak W Mak and Daniel Nathan Sauder},
  journal={The Journal of investigative dermatology},
  year={1996},
  volume={106 5},
  pages={993-1000}
}
To determine the role of CD4 molecules in the generation and regulation of contact hypersensitivity (CHS), we treated mice lacking the CD4 gene as a result of targeted disruption with dinitrofluorobenzene to induce CHS. The mutant mice lacking CD4 (CD4(-) mice) showed marked hyporesponsiveness in CHS compared with normal syngeneic C57BL/6 mice (38.3 +/-9.0% of normal at 24 h after the challenge assessed by net ear swelling; p < 0.025). CD4(-) mice had a larger CD4-8- double negative T-cell… CONTINUE READING

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