Corpus ID: 28752661

Hypoprothrombinemia resulting from the administration of sulfaquinoxaline.

  title={Hypoprothrombinemia resulting from the administration of sulfaquinoxaline.},
  author={Charles W. Mushett and Albert O. Seeler},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={91 1},
  • C. W. Mushett, A. Seeler
  • Published 1 September 1947
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental therapeutics
The mode of action of sulfaquinoxaline in inducing a prompt hypoprothrombinemia does not appear to be related to anatomic changes in the liver or to inhibition of intestinal bacteria. Although this compound does not destroy or inactivate prothrombin in vitro, the possibility of such an action in vivo has not been excluded. The rapid prothrombinopenic effect of sulfaquinoxaline cannot be attributed alone to either the sulfanilamido or the quinoxaline portion of the molecule, but is due to the… Expand
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