Hypopituitarism As a Consequence of Brain Tumours and Radiotherapy

  title={Hypopituitarism As a Consequence of Brain Tumours and Radiotherapy},
  author={Ken H. Darzy and Stephen M. Shalet},
Radiation-induced damage to the hypothalamic-pituitary (h-p) axis is associated with a wide spectrum of subtle and frank abnormalities in anterior pituitary hormones secretion. The frequency, rapidity of onset and the severity of these abnormalities correlate with the total radiation dose delivered to the h-p axis, as well as the fraction size, younger age at irradiation, prior pituitary compromise by tumour and/or surgery and the length of follow up. Whilst, the hypothalamus is the primary… CONTINUE READING
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