Hypopigmentation in dogs treated with an inhibitor of platelet aggregation.

@article{Walsh1989HypopigmentationID,
  title={Hypopigmentation in dogs treated with an inhibitor of platelet aggregation.},
  author={Kathleen M. Walsh and Alexander Gough},
  journal={Toxicologic pathology},
  year={1989},
  volume={17 3},
  pages={549-53}
}
Hypopigmentation was the principal manifestation of systemic toxicity when the experimental platelet aggregation inhibitor, PD-89454, was orally administered to Beagle dogs for 28 days. Pigmentation changes were present in skin of nose, lips and eyelids and mucosa of hard palate. Fontana-Masson stain demonstrated decreased melanin within melanocytes and… CONTINUE READING