Hypophysiotropic role and hypothalamic gene expression of corticotropin-releasing factor and vasopressin in rats injected with interleukin-1 beta systemically or into the brain ventricles.

Intact adult male rats were injected intravenously (i.v., 400 ng/kg), intraperitoneally (i.p., 400 ng/kg) or intracerebroventricularly (i.c.v., 100 ng/kg) with interleukin-1 beta (IL-1 beta) or its vehicle. In comparison with vehicle-treated animals, IL-1 beta induced significant (P < 0.01) increases in plasma ACTH levels measured 30 min later regardless of… CONTINUE READING