Hypophosphatemia: the common denominator of all rickets

@article{Tiosano2009HypophosphatemiaTC,
  title={Hypophosphatemia: the common denominator of all rickets},
  author={Dov Tiosano and Ze’ev Hochberg},
  journal={Journal of Bone and Mineral Metabolism},
  year={2009},
  volume={27},
  pages={392-401}
}
Rickets is a disease of the hypertrophic chondrocytes in the growth plate and is caused by hypophosphatemia—a derived defect in terminal chondrocyte apoptosis. This highlights the critical role of phosphorous in cartilage and bone metabolism. This review shows the role of phosphorous metabolism, transport and function in maintaining phosphorous supply to the growth plate, bone osteoblast and the kidney. Given that phosphorous is the common denominator of all rickets, this review proposes a new… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 48 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 61 references

Similar Papers

Loading similar papers…