Hypophosphatemia, hyperphosphaturia, and bisphosphonate treatment are associated with survival beyond infancy in generalized arterial calcification of infancy.

@article{Rutsch2008HypophosphatemiaHA,
  title={Hypophosphatemia, hyperphosphaturia, and bisphosphonate treatment are associated with survival beyond infancy in generalized arterial calcification of infancy.},
  author={Frank Rutsch and Petra B{\"o}yer and Yvonne Nitschke and Nico Ruf and Bettina Lorenz-Depierieux and Tanja Wittkampf and Gabriele Weissen-Plenz and R. Fischer and Zulf M. Mughal and John Welbourn Gregory and J H Davies and Chantal Loirat and Tim Matthias Strom and Dirk Schnabel and Peter N{\"u}rnberg and Robert Terkeltaub},
  journal={Circulation. Cardiovascular genetics},
  year={2008},
  volume={1 2},
  pages={
          133-40
        }
}
BACKGROUND Generalized arterial calcification of infancy has been reported to be frequently lethal, and the efficiency of any therapy, including bisphosphonates, is unknown. A phosphate-poor diet markedly increases survival of NPP1 null mice, a model of generalized arterial calcification of infancy. METHODS AND RESULTS We performed a multicenter genetic study and retrospective observational analysis of 55 subjects affected by generalized arterial calcification of infancy to identify… CONTINUE READING

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