Hyponatremia associated with Ipilimumab-induced hypophysitis.


A 75-year-old woman with a history of stage IV metastatic melanoma underwent treatment with the CTLA-4 blocking agent Ipilimumab. She presented 2 months after initiating treatment with a severe headache. Laboratories were consistent with severe hyponatremia. MRI of the brain revealed enlargement of the pituitary gland, enhancement of the infundibulum, and… (More)
DOI: 10.1007/s12032-010-9794-7

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