Hyponatremia among runners in the Boston Marathon.

@article{Almond2005HyponatremiaAR,
  title={Hyponatremia among runners in the Boston Marathon.},
  author={Christopher S. D. Almond and Andrew Young Shin and Elizabeth B. Fortescue and Rebekah Mannix and David Wypij and Bryce A. Binstadt and Christine N. Duncan and David P. Olson and Annalisa Salerno and Jane W. Newburger and David S. Greenes},
  journal={The New England journal of medicine},
  year={2005},
  volume={352 15},
  pages={
          1550-6
        }
}
BACKGROUND Hyponatremia has emerged as an important cause of race-related death and life-threatening illness among marathon runners. [...] Key Method Subjects completed a survey describing demographic information and training history. After the race, runners provided a blood sample and completed a questionnaire detailing their fluid consumption and urine output during the race. Prerace and postrace weights were recorded.Expand
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Hyponatremia has been associated with high fluid intake in races performed under cool weather, such as the Boston Marathon during spring, and hypernatremia was found in a half marathon in warm and humid weather, which was associated with lower volume and frequency of fluid intake. Expand
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TLDR
On-site sodium testing and treatment in collapsed runners at the finish-line medical tent at the Boston marathons from 2001 through 2008 was reviewed, finding dysnatremic runners treated with appropriate intravenous fluids according to validated standards of care. Expand
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Cases of EAH fulfill the essential diagnostic criteria for the syndrome of inappropriate antidiuretic hormone secretion (SIADH), and runners with hypotonic encephalopathy at subsequent races were treated with intravenous hypertonic saline on the basis of this paradigm, which resulted in rapid clinical improvement without adverse effects. Expand
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