Hypomorphic mutation of the TALE gene Prep1 (pKnox1) causes a major reduction of Pbx and Meis proteins and a pleiotropic embryonic phenotype.

@article{Ferretti2006HypomorphicMO,
  title={Hypomorphic mutation of the TALE gene Prep1 (pKnox1) causes a major reduction of Pbx and Meis proteins and a pleiotropic embryonic phenotype.},
  author={Elisabetta Ferretti and Juan Carlos Villaescusa and Patrizia Di Rosa and Luis C Fernandez-D{\'i}az and Elena Longobardi and Roberta Mazzieri and Annarita Miccio and Nicola Micali and Licia Selleri and Giuliana Ferrari and Francesco Blasi},
  journal={Molecular and cellular biology},
  year={2006},
  volume={26 15},
  pages={5650-62}
}
The interaction of Prep1 and Pbx homeodomain transcription factors regulates their activity, nuclear localization, and likely, function in development. To understand the in vivo role of Prep1, we have analyzed an embryonic lethal hypomorphic mutant mouse (Prep1(i/i)). Prep1(i/i) embryos die at embryonic day 17.5 (E17.5) to birth with an overall organ hypoplasia, severe anemia, impaired angiogenesis, and eye anomalies, particularly in the lens and retina. The anemia correlates with delayed… CONTINUE READING

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