Hypomorphic mutation in hnRNP U results in post-implantation lethality

@article{Roshon2004HypomorphicMI,
  title={Hypomorphic mutation in hnRNP U results in post-implantation lethality},
  author={Michael J. Roshon and H. Earl. Ruley},
  journal={Transgenic Research},
  year={2004},
  volume={14},
  pages={179-192}
}
The present study characterized an embryonic lethal mutation induced by insertion of the U3Neo gene trap retrovirus into an intron of the gene encoding heterogeneous ribonuclear protein U (Hnrnpu), which maps to the distal arm of mouse chromosome 1. Murine hnRNP U was found to be identical to the human protein at all but one of 341 amino acid residues. Embryos homozygous for the provirus showed obvious abnormalities after 6.5 days of development (E6.5) and were resorbed by E10.5. Expression of… CONTINUE READING

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