Hypomorphic Smn knockdown C2C12 myoblasts reveal intrinsic defects in myoblast fusion and myotube morphology.

@article{Shafey2005HypomorphicSK,
  title={Hypomorphic Smn knockdown C2C12 myoblasts reveal intrinsic defects in myoblast fusion and myotube morphology.},
  author={Dina Shafey and Patrice D. C{\^o}t{\'e} and Rashmi Kothary},
  journal={Experimental cell research},
  year={2005},
  volume={311 1},
  pages={49-61}
}
Dosage of the survival motor neuron (SMN) protein has been directly correlated with the severity of disease in patients diagnosed with spinal muscular atrophy (SMA). It is also clear that SMA is a neurodegenerative disorder characterized by the degeneration of the alpha-motor neurons in the anterior horn of the spinal cord and atrophy of the associated skeletal muscle. What is more controversial is whether it is neuronal and/or muscle-cell-autonomous defects that are responsible for the disease… CONTINUE READING
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