Hypomethylation of the IL17RC promoter associates with age-related macular degeneration.

@article{Wei2012HypomethylationOT,
  title={Hypomethylation of the IL17RC promoter associates with age-related macular degeneration.},
  author={Lai Wei and Baoying Liu and Jingsheng Tuo and Defen Shen and Ping Chen and Zhiyu Li and Xunxian Liu and Jia Ni and Pradeep Dagur and H. Nida Sen and Shayma M Jawad and Diamond Ling and Stanley Park and Sagarika Chakrabarty and Catherine B. Meyerle and Elvira Agr{\'o}n and Frederick L. Ferris and Emily Y. Chew and J. Philip McCoy and Emily Blum and Peter Francis and Michael L. Klein and Robyn H. Guymer and Paul N Baird and C. -K. Chan and Robert B. Nussenblatt},
  journal={Cell reports},
  year={2012},
  volume={2 5},
  pages={1151-8}
}
Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in the elderly population worldwide. Although recent studies have demonstrated strong genetic associations between AMD and SNPs in a number of genes, other modes of regulation are also likely to play a role in the etiology of this disease. We identified a significantly decreased level of methylation on the IL17RC promoter in AMD patients. Furthermore, we showed that hypomethylation of the IL17RC promoter in… CONTINUE READING

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