Hypomethylation of retrotransposable elements correlates with genomic instability in non-small cell lung cancer.

@article{Daskalos2009HypomethylationOR,
  title={Hypomethylation of retrotransposable elements correlates with genomic instability in non-small cell lung cancer.},
  author={Alexandros Daskalos and Georgios Nikolaidis and George E Xinarianos and Paraskevi Savvari and Adrian Cassidy and Roubini N Zakopoulou and Athanasios Kotsinas and Vassilis G Gorgoulis and John K. Field and Triantafillos Liloglou},
  journal={International journal of cancer},
  year={2009},
  volume={124 1},
  pages={81-7}
}
LINE-1 and Alu elements are non-LTR retrotransposons, constituting together over 30% of the human genome and they are frequently hypomethylated in human tumors. A relationship between global hypomethylation and genomic instability has been shown, however, there is little evidence to suggest active role for hypomethylation-mediated reactivation of retroelements in human cancer. In our study, we examined by Pyrosequencing the methylation levels of LINE-1 and Alu sequences in 48 primary nonsmall… CONTINUE READING

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