Hypomethylation of WNT5A, CRIP1 and S100P in prostate cancer

  title={Hypomethylation of WNT5A, CRIP1 and S100P in prostate cancer},
  author={Qiang Wang and Magali Williamson and Simon R J Bott and Nicola Brookman-Amissah and Alex Freeman and Joseph Nariculam and Michael Hubank and Aisha Shamsuna Ahmed and John R. W. Masters},
Oligoarray analysis of a matched pair of prostate cancer and normal cell lines derived from the same radical prostatectomy specimen identified 113 candidate hypomethylated genes that were overexpressed in the cancer cells and contained CpG islands. Hypomethylation of wingless-related MMTV integration site 5A (WNT5A), S100 calcium-binding protein P (S100P) and cysteine-rich protein 1(CRIP1) was confirmed in the cancer cells by bisulfite sequencing. Treatment of the corresponding normal prostate… CONTINUE READING