Hypomethylation of LINE1 retrotransposon in human hepatocellular carcinomas, but not in surrounding liver cirrhosis.

@article{Takai2000HypomethylationOL,
  title={Hypomethylation of LINE1 retrotransposon in human hepatocellular carcinomas, but not in surrounding liver cirrhosis.},
  author={Daiya Takai and Yasuo Yagi and Nagy Habib and Takashi Sugimura and Toshikazu Ushijima},
  journal={Japanese journal of clinical oncology},
  year={2000},
  volume={30 7},
  pages={306-9}
}
BACKGROUND Cytosine methylation of LINE1 (L1) elements, some of which are capable of retrotransposition in human cells, is known to play important roles in transcriptional repression of these retrotransposons. We have previously identified consistent hypomethylation of L1 elements in mouse liver tumors by a genome-wide search technique for aberrant… CONTINUE READING