Hypometabolism exceeds atrophy in presymptomatic early-onset familial Alzheimer's disease.

@article{Mosconi2006HypometabolismEA,
  title={Hypometabolism exceeds atrophy in presymptomatic early-onset familial Alzheimer's disease.},
  author={Lisa Mosconi and Sandro Sorbi and Mony J. de Leon and Yi Li and Benedetta Nacmias and Paul S Myoung and Wai Tsui and Andrea Ginestroni and Valentina Bessi and Mozghan Fayyazz and Paolo Caffarra and Alberto Pupi},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year={2006},
  volume={47 11},
  pages={1778-86}
}
UNLABELLED The aim of the present study is to compare brain atrophy with hypometabolism as preclinical markers of Alzheimer's disease (AD) by studying presymptomatic individuals from families with known early-onset autosomal dominant AD (FAD) carrying mutations in the Presenilin 1 gene. METHODS Seven asymptomatic at-risk FAD individuals (age, 35-49 y; 4… CONTINUE READING