Hypolipidemic effects of 6-amino-2-mercapto-5-methylpyrimidine-4-carboxylic acid in rats and tissue culture cells.

@article{Hall1993HypolipidemicEO,
  title={Hypolipidemic effects of 6-amino-2-mercapto-5-methylpyrimidine-4-carboxylic acid in rats and tissue culture cells.},
  author={Iris H. Hall and Oi T. Wong and David J. Reynolds and Rupendra Simlot and Jessica J Chang},
  journal={Journal of pharmaceutical sciences},
  year={1993},
  volume={82 1},
  pages={60-8}
}
6-Amino-2-mercapto-5-methylpyrimidine-4-carboxylic acid (AMMPCA) was found to be a potent hypolipidemic agent at oral doses of 10 and 20 mg/kg/day in rodents. This agent was observed to affect de novo lipid synthesizing enzyme activities in a manner that resulted in lower lipid levels in tissues including the aorta wall. Very low density lipoprotein and low… CONTINUE READING