Hypolipidemic Activity in Rodents of Phenobarbital and Related Derivatives

@article{Hall1990HypolipidemicAI,
  title={Hypolipidemic Activity in Rodents of Phenobarbital and Related Derivatives},
  author={Iris H. Hall and M. A. Patrick and James H. Maguire},
  journal={Archiv der Pharmazie},
  year={1990},
  volume={323}
}
A series of 5‐alkyl‐5‐phenylbarbituric acid analogues were shown to be potent hypolipidemic agents in rats and mice at 20 mg/kg/day. This dose is tower than that required for hypolipidemic activity for clofibrate and nicotinic acid derivatives in rodents and man. These new derivatives reduced both serum cholesterol and triglyceride levels in rodents by either the oral or intraperitoneal route of administration. Previous studies have demonstrated that similar heterocyclic compounds, i.e. cyclic… 
Investigation of 3,5-Isoxazolidinediones as Hypolipidemic Agents in Rodents
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Two compounds, 1-methyl-4-piperidyl bis (p-chlorophenoxy) acetate and 1,3-bis ( p-methylphenoxy)-2-propanone were the best inhibitors of glycerolipid biosynthesis and lipid-lowering agents and were compared to chlorophenoxyisobutyrate during high fructose intake in rats.
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Cholesterol distribution studies showed that the 3H-content was lowered in the major organs but was elevated in the chyme and stomach, suggesting that the drug accelerated bile secretion of cholesterol or its metabolites.
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In vivo studies suggest that antiepileptic phenylhydantoins, when used in chronic therapy in man, could possibly act as hypolipidemic agents.
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TLDR
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TLDR
It is revealed that the chain length, as well as the type of substitution on the N-alkyl chain of phthalimide is critical for biological activity, and in these studies the hypolipidemic activity was not improved by extending the chainlength beyond five carbon atoms in the alkyl and alkanoic acid series.
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TLDR
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TLDR
A series of compounds related to ethyl 4-benzyloxybenzoate was synthesized and evaluated for potential hypolipidemic activity in rats to discuss structure--activity relationships and effects on weight gain and liver lipids.
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The results of these studies are in accord with the concept that the presence of a Delta(5)-double bond is not required for the enzymatic formation of the 7alpha-hydroxy derivative.
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