Hypolipidaemic activity of aqueous ocimum basilicum extract in acute hyperlipidaemia induced by triton WR‐1339 in rats and its antioxidant property

  title={Hypolipidaemic activity of aqueous ocimum basilicum extract in acute hyperlipidaemia induced by triton WR‐1339 in rats and its antioxidant property},
  author={Souliman Amrani and Hicham Harnafi and Nour el Houda Bouanani and Mohammed Aziz and Hana Serghini Caid and Stefano Manfredini and Elena Besco and Mariarosaria Napolitano and Elena Bravo},
  journal={Phytotherapy Research},
Hyperlipidaemia, atherosclerosis and related diseases are becoming a major health problem in developing countries. Ocimum basilicum is one of the medicinal plants widely used in Morocco to reduce plasma cholesterol and to reduce the risk of atherosclerosis‐related diseases. However, mechanisms underlying the reported hypolipidaemic effect of this plant have not been investigated. This study evaluates the lipid lowering effect of aqueous Ocimum basilicum extract in Triton WR‐1339‐induced… 

Mechanisms of Hepato-Renal Protective Activity of Ocimum basilicum Leaf Extract against Paracetamol Toxicity in Rat Model

The findings indicated that O. basilicum extract has a hepato-renal protective activity against paracetamol induced toxicity in rats, and this protection may be attributed to good antioxidant activity of O. Basilicum.

Favorable effects of dill tablets and Ocimum basilicum L. extract on learning, memory, and hippocampal fatty acid composition in hypercholesterolemic rats

Dill tablets and aqueous extract of basil attenuated the hypercholesterolemia-induced memory impairment by lowering serum cholesterol and hippocampus amyloid deposits, and probably beneficial in AD adjuvant therapy.

Dill tablet and Ocimum basilicum aqueous extract: Promising therapeutic agents for improving cognitive deficit in hypercholesterolemic rats.

Beneficial therapeutic effects of Dill tablet and Ocimum basilicum (Basil) aqueous extract on hypercholesterolemia-induced cognitive deficits and oxidative stress in hippocampus tissues of rats are investigated suggesting that these medicinal plants can be considered as surrogate therapeutic agents for the synthetic medicines in the treatment of AD and in postponement of its complications.

Effect of polyphenol, flavonoid, and saponin fractions from Thymus atlanticus on acute and chronic hyperlipidemia in mice

P phenolic compounds from Thymus atlanticus possess a significant hypocholesterolemic and hypotriglyceridemic effects and, therefore, could have an important role in the management of dyslipidemia.


The objective of this work to study the therapeutic effect of volatile oils and alcoholic aqueous extracts of basil and thyme leaves in blood glucose and lipid profile of alloxan- induced in diabetic

Hypolipidemic and antioxidative effects of dika nut (Irvingia gabonensis) seeds and nkui (Trimphetta cordifolia) stem bark mucilages in triton WR-1339 induced hyperlipidemic rats

Two different mucilages were extracted from dika nut (Irvingia gabonensis) kernels and nkui (Trimphetta cordifolia) stem barks and the hypolipidemic and antioxidant effects were studied on Triton

Antihypertensive effects of Ocimum basilicum L. (OBL) on blood pressure in renovascular hypertensive rats

The effects of OBL on blood pressure, cardiac hypertrophy and ET, are consistent with an effect on ET-converting enzyme, and warrant further exploration.



Hypolipidemic activity of Achyranthus aspera Linn in normal and triton induced hyperlipemic rats.

The alcoholic extract of A. aspera, at 100 mg/kg dose lowered serum cholesterol (TC), phospholipid (PL). triglyceride (TG) and total lipids (TL) levels by 60, 51, 33 and 53% respectively in triton

Triton-induced hyperlipidemia in rats as an animal model for screening hypolipidemic drugs

We describe a screening test for hypolipidemic agents in which compounds are administered orally to fasted rats after a single intravenous injection of 225 mg Triton WR-1339/kg and serum cholesterol

Phenolics composition and antioxidant activity of sweet basil (Ocimum basilicum L.).

The antioxidant activity of a methanolic extract of Ocimum basilicum L. (sweet basil) was examined using different in vitro assay model systems and the existence of a synergistic effect between alpha-tocopherol and rosmarinic acid was revealed.

Grape seed procyanidins improve atherosclerotic risk index and induce liver CYP7A1 and SHP expression in healthy rats

Procyanidins improve the atherosclerotic risk index in the postprandial state, inducing in the liver the overexpression of CYP7A1 (suggesting an increase of cholesterol elimination via bile acids) and SHP, a nuclear receptor emerging as a key regulator of lipid homeostasis at the transcriptional level.

Evaluation of gastric anti-ulcer activity of fixed oil of Ocimum basilicum Linn. and its possible mechanism of action.

  • S. Singh
  • Medicine, Biology
    Indian journal of experimental biology
  • 1999
Fixed oil of O. basilicum was found to possess significant antiulcer activity against aspirin, indomethacin, alcohol, histamine, reserpine, serotonin and stress-induced ulceration in experimental

Hypotriglyceridaemic activity of Ficus carica leaves in experimental hypertriglyceridaemic rats

A model of hypertriglyceridaemia in rats is described, which was used to investigate the hypolipidaemic effect of an intraperitoneal (i./p.) administration of a Ficus carica leaf decoction.