Hypogonadotropic hypogonadism: hormonal responses to low dose pulsatile administration of gonadotropin-releasing hormone.

@article{Valk1980HypogonadotropicHH,
  title={Hypogonadotropic hypogonadism: hormonal responses to low dose pulsatile administration of gonadotropin-releasing hormone.},
  author={T W Valk and K P Corley and Robert P. Kelch and John C. Marshall},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1980},
  volume={51 4},
  pages={730-8}
}
Patients with isolated gonadotropin deficiency were studied to determine whether pulsatile low dose gonadotropin-releasing hormone (GnRH) could induce the hormonal changes seen during normal puberty. Four male and two female patients with immature responses to a standard GnRH test (2.5 micrograms/kg) were given GnRH (0.025 micrograms/kg) iv every 2 h for 5 days. FSH responses varied between the sexes, and FSH concentrations in males rose continuously to 17.2 +/- 4.7 mIU/ml on day 5. In the… CONTINUE READING

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