Hypoglycemic effects of insulin-like growth factor-1 in experimental uremia: can concomitant growth hormone administration prevent this effect?

@article{Kovacs1999HypoglycemicEO,
  title={Hypoglycemic effects of insulin-like growth factor-1 in experimental uremia: can concomitant growth hormone administration prevent this effect?},
  author={Gabor Thomas Kovacs and Stefan Worgall and P. Schwalbach and T. Steichele and Otto Mehls and L{\'a}szl{\'o} Rosivall},
  journal={Hormone research},
  year={1999},
  volume={51 4},
  pages={193-200}
}
The risk of hypoglycemia limits the clinical application of insulin-like growth factor-1 (IGF-1). Our studies aimed to evaluate the mode of occurrence as well as the prevention of this side effect. Acute administration (i.v. infusion) of IGF-1 in subtotal nephrectomized uremic (U), sham-operated ad libitum fed control (C) and sham-operated pair-fed control (P) rats led to hypoglycemia, though more expressed in P. Serum glucose levels decreased within 60 min after the IGF-1 administration by 40… CONTINUE READING