Hypoglycemic effect of isoleucine involves increased muscle glucose uptake and whole body glucose oxidation and decreased hepatic gluconeogenesis.

@article{Doi2007HypoglycemicEO,
  title={Hypoglycemic effect of isoleucine involves increased muscle glucose uptake and whole body glucose oxidation and decreased hepatic gluconeogenesis.},
  author={M. Doi and I. Yamaoka and M. Nakayama and K. Sugahara and F. Yoshizawa},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2007},
  volume={292 6},
  pages={
          E1683-93
        }
}
  • M. Doi, I. Yamaoka, +2 authors F. Yoshizawa
  • Published 2007
  • Chemistry, Medicine, Biology
  • American journal of physiology. Endocrinology and metabolism
Isoleucine, a branched chain amino acid, plays an important role in the improvement of glucose metabolism as evidenced by the increase of insulin-independent glucose uptake in vitro. [...] Key Result Oral administration of isoleucine decreased the plasma glucose level by 20% and significantly increased muscle glucose uptake by 71% without significant elevation of the plasma insulin level compared with controls at 60 min after administration.Expand
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