Hypoglycemic effect of isoleucine involves increased muscle glucose uptake and whole body glucose oxidation and decreased hepatic gluconeogenesis.

@article{Doi2007HypoglycemicEO,
  title={Hypoglycemic effect of isoleucine involves increased muscle glucose uptake and whole body glucose oxidation and decreased hepatic gluconeogenesis.},
  author={Masako Doi and Ippei Yamaoka and Mitsuo Nakayama and Kunio Sugahara and Fumiaki Yoshizawa},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2007},
  volume={292 6},
  pages={
          E1683-93
        }
}
  • M. Doi, I. Yamaoka, F. Yoshizawa
  • Published 1 March 2007
  • Biology, Medicine
  • American journal of physiology. Endocrinology and metabolism
Isoleucine, a branched chain amino acid, plays an important role in the improvement of glucose metabolism as evidenced by the increase of insulin-independent glucose uptake in vitro. [] Key Result Oral administration of isoleucine decreased the plasma glucose level by 20% and significantly increased muscle glucose uptake by 71% without significant elevation of the plasma insulin level compared with controls at 60 min after administration.

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