Hypoglycemic effect of isoleucine involves increased muscle glucose uptake and whole body glucose oxidation and decreased hepatic gluconeogenesis.
@article{Doi2007HypoglycemicEO, title={Hypoglycemic effect of isoleucine involves increased muscle glucose uptake and whole body glucose oxidation and decreased hepatic gluconeogenesis.}, author={Masako Doi and Ippei Yamaoka and Mitsuo Nakayama and Kunio Sugahara and Fumiaki Yoshizawa}, journal={American journal of physiology. Endocrinology and metabolism}, year={2007}, volume={292 6}, pages={ E1683-93 } }
Isoleucine, a branched chain amino acid, plays an important role in the improvement of glucose metabolism as evidenced by the increase of insulin-independent glucose uptake in vitro. [] Key Result Oral administration of isoleucine decreased the plasma glucose level by 20% and significantly increased muscle glucose uptake by 71% without significant elevation of the plasma insulin level compared with controls at 60 min after administration.
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