Hypoglycemic effect of Lupinus mutabilis in healthy volunteers and subjects with dysglycemia.

@article{Fornasini2012HypoglycemicEO,
  title={Hypoglycemic effect of Lupinus mutabilis in healthy volunteers and subjects with dysglycemia.},
  author={Marco Fornasini and Jos{\'e} Armando Justinico Castro and Elena Villacr{\'e}s and Luis Narv{\'a}ez and Marly Villamar and Manuel E. Balde{\'o}n},
  journal={Nutricion hospitalaria},
  year={2012},
  volume={27 2},
  pages={
          425-33
        }
}
Metabolic syndrome and type-2 diabetes are increasing health problems that negatively affect health care systems worldwide. There is a constant urge to develop new therapies with better effects, lower side effects at lower prices to treat these diseases. Lupinus species and their derivates are good candidates to be used as hypoglycaemic agents. A phase II clinical trial was conducted to assess the role of raw Lupinus mutabilis on blood glucose and insulin in normoglycemic and dysglycemic… 

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References

SHOWING 1-10 OF 24 REFERENCES

Conglutin gamma, a lupin seed protein, binds insulin in vitro and reduces plasma glucose levels of hyperglycemic rats.

Plasma glucose lowering effect of spartein sulphate infusion in non-insulin dependent (Type 2) diabetic subjects

It is concluded that sparteine sulphate enhances β-cell secretion, causing a fall in the plasma glucose concentration, and increases plasma insulin and decreases plasma glucose and adrenaline in non-insulin dependent (Type II) diabetic subjects.

Quinolizidine alkaloids isolated from Lupinus species enhance insulin secretion.

Effect of sparteine sulphate upon basal and nutrient-induced insulin and glucagon secretion in normal man

Infusion of a therapeutic dose of sparteine sulphate, increased the basal plasma insulin level and lowered plasma glucose and increased both basal and nutrient-induced insulin and glucagon secretion in normal man.

Pharmacogenetics and future strategies in treating hyperglycaemia in diabetes.

  • E. Pearson
  • Medicine, Biology
    Frontiers in bioscience
  • 2009
This review focuses on current evidence for pharmacogenetics for the 3 commonly used drug classes in treating diabetes: metformin, sulphonylureas and thiazolidinediones. Currently, metformin

Polymorphic drug metabolism in schizophrenic patients with tardive dyskinesia.

There was no overrepresentation of PM of debrisoquine or of S-mephenytoin among the 16 patients with neuroleptic-induced tardive dyskinesia, however, the PM ofbrisoquine had the highest score on the Simpson-Angus Rating Scale and the second highest on the Abnormal Involuntary Movement Scale, despite a very low Neuroleptic dose.

Disposition of lupanine and 13-hydroxylupanine in man.

Overall, the finding of a high urinary recovery of unchanged lupanine or 13-hydroxyl upanine together with similar t1/2s for both alkaloids in EM and PM CYP2D6 phenotypes suggests that clinical toxicity is unlikely to result from the use of lupin seed in footstuffs.

Use and abuse of HOMA modeling.

The HOMA model has become a widely used clinical and epidemiological tool and, when used appropriately, it can yield valuable data, however, as with all models, the primary input data needs to be robust, and the data need to be interpreted carefully.

Diabetes and obesity: the twin epidemics

As the overall cost of diabetes management far outweighs the relative costs of drug therapy, there are powerful health and economic arguments in favor of using drugs that improve glycemic control, leading to a decline in rates of hospitalization and premature deaths.