Hypoglycemic effect of Astragalus polysaccharide and its effect on PTP1B

@article{Wu2005HypoglycemicEO,
  title={Hypoglycemic effect of Astragalus polysaccharide and its effect on PTP1B},
  author={Yong Wu and Jing-ping Ou-yang and Ke Wu and Ya Wang and Yun-feng Zhou and Chong-yuan Wen},
  journal={Acta Pharmacologica Sinica},
  year={2005},
  volume={26},
  pages={345-352}
}
AbstractAim:To examine the effects of Astragalus polysaccharide (APS), a component of an aqueous extract of Astragalus membranaceus roots, on protein tyrosine phosphatase 1B (PTP1B), a negative regulator of insulin-receptor (IR) signal transduction, and its potential role in the amelioration of insulin resistance.Methods:Ten-week-old fat-fed streptozotocin (STZ)-treated rats, an animal model of type II diabetes mellitus (TIIDM), were treated with APS (400 mg/kg po) for 5 weeks. Insulin… CONTINUE READING