Hypoglycemic diterpenoids from Tinospora crispa.

@article{Lam2012HypoglycemicDF,
  title={Hypoglycemic diterpenoids from Tinospora crispa.},
  author={Sio-Hong Lam and Chi-Tun Ruan and Po-Hung Hsieh and Ming Jai Su and Shoei‐Sheng Lee},
  journal={Journal of natural products},
  year={2012},
  volume={75 2},
  pages={
          153-9
        }
}
Three new diterpenoids, 2-O-lactoylborapetoside B (1), 6'-O-lactoylborapetoside B (2), and tinocrispol A (3), and nine known diterpenoids (4-12) were isolated from an EtOH extract of Tinospora crispa vines. Their structures were elucidated by spectroscopic analyses. The C-6 glucosyloxy group in borapetoside C (6) was revised to be α-oriented. The in vivo hypoglycemic activities of the major components, borapetosides A-C (4-6), were examined. Intraperitoneal injection of 4 and 6 (5 mg/kg) showed… 
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References

SHOWING 1-10 OF 25 REFERENCES
cis-Clerodane-type furanoditerpenoids from Tinospora crispa.
Phytochemical and cytotoxicity investigations on organic solvent extracts of the aerial parts of Tinospora crispa have led to the isolation of 15 cis-clerodane-type furanoditerpenoids. Of these, nine
Oleanane Saponins and Glycerogalactolipids from the Leaves of Guapira graciliflora
Two new saponins, 3-O-[β-D-xylopyranosyl-(13)-β-D-galactopyranosyl-(13)-β-glucuronopyranosyl]oleanolic acid 28-O-β-D-glucopyranosyl ester (1) and the corresponding monodesmoside,
The hypoglycaemic and insulinotropic activity of Tinospora crispa: studies with human and rat islets and HIT-T15 B cells
TLDR
These are the first studies to provide biochemical evidence which substantiates the traditional claims for an oral hypoglycaemic effect of Tinospora crispa, and which also show that the hypoglyCAemic effect is associated with increased insulin secretion.
Antidiabetic effects of Tinospora crispa in rats.
Studies on the Constituents of the Stems of Tinospora tuberculata, IV. Isolation and Structure Elucidation of the Five New Furanoid Diterpene Glycosides Borapetoside C–G
Five new furanoid diterpene glycosides, named borapetoside C (1), D (2), E (3), F (4), and G (5), were isolated from the stems of Tinospora tuberculata Beumee (Menispermaceae). The structures of 1–5
Insulin secretion and cyclooxygenase enzyme inhibition by cabernet sauvignon grape skin compounds.
TLDR
This is the first report of beta-sitosterol-6'-linolenoyl-3-O-beta-D-glucopyranoside from grape skin and insulin secretion activities of compounds 4 and 5, which showed a dose-dependent insulin production in this assay.
Antihyperglycemic effect of a caffeamide derivative, KS370G, in normal and diabetic mice.
TLDR
It was found that KS370G could stimulate the release of insulin in both normal and T2DM mice, and a dose of 1 mg per kg KS 370G could significantly attenuate the increase of plasma glucose induced by an intraperitoneal glucose challenge test in normal and diabetic mice.
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