Hypoglycemic diterpenoids from Tinospora crispa.

  title={Hypoglycemic diterpenoids from Tinospora crispa.},
  author={Sio-Hong Lam and Chi-Tun Ruan and Po-Hung Hsieh and Ming Jai Su and Shoei‐Sheng Lee},
  journal={Journal of natural products},
  volume={75 2},
Three new diterpenoids, 2-O-lactoylborapetoside B (1), 6'-O-lactoylborapetoside B (2), and tinocrispol A (3), and nine known diterpenoids (4-12) were isolated from an EtOH extract of Tinospora crispa vines. Their structures were elucidated by spectroscopic analyses. The C-6 glucosyloxy group in borapetoside C (6) was revised to be α-oriented. The in vivo hypoglycemic activities of the major components, borapetosides A-C (4-6), were examined. Intraperitoneal injection of 4 and 6 (5 mg/kg) showed… 
Clerodane Diterpenoids with Anti-hyperglycemic Activity from Tinospora crispa
Compound 1 significantly reduced serum glucose levels at dose-dependent manners in alloxan-induced hyperglycemic mice and db/db type 2 diabetic mice.
Clerodane Diterpenoid Glucosides from the Stems of Tinospora sinensis.
Ten new clerodane diterpenoid glucosides and three known analogues were isolated from an EtOAc extract of the stems of Tinospora sinensis and showed cytotoxicity against the human epithelioid cervical carcinoma cell line and nitric oxide production inhibitory activity of lipopolysaccharide-activated N9 microglial cells.
Clerodane furanoditerpenoids from the stems of Tinospora sinensis.
One new clerodane-type furanoditerpenoid tinosinoid A (1) and nine new nor-clerodane analogs tinosinoids B-J (2-10) have been isolated from the stems of Tinospora sinensis. The structures of the new
Hypoglycemic action of borapetoside A from the plant Tinospora crispa in mice.
Rearranged Clerodane Diterpenoids from the Stems of Tinospora baenzigeri.
Four new rearranged clerodane-type diterpenoids, a new glucoside, and six known compounds were obtained from the EtOAc crude extract of Tinospora baenzigeri stem and showed protective effect against N-acetyl- p-aminophenol (APAP)-induced HepG2 cell damage.
Two new rearranged clerodane diterpenes from Thai Tinospora baenzigeri
The isolated compounds were evaluated for their cytotoxicity against Hep-G2 and MCF-7 cancer cells, none of them did show any significant activity at 25 μM, which is a rare example of rearranged clerodanes.
Review of Anti-Hyperglycemic Effect of Tinospora crispa
In human studies, T. crispa extract possesses a significant anti-hyperglycemic effect in metabolic syndrome but this effect is abolished in type 2 diabetes mellitus.
Antidiabetic Effect of Oral Borapetol B Compound, Isolated from the Plant Tinospora crispa, by Stimulating Insulin Release
This study provides evidence that borapetol B (C1) has antidiabetic properties mainly due to its stimulation of insulin release, and perifusion experiments indicated that C1 did not cause leakage of insulin by damaging islet beta cells.
Borapetoside E, a Clerodane Diterpenoid Extracted from Tinospora crispa, Improves Hyperglycemia and Hyperlipidemia in High-Fat-Diet-Induced Type 2 Diabetes Mice.
Borapetoside E showed beneficial effects in vivo, demonstrating that borapetside E may be a potential therapy for the treatment of diet-induced type 2 diabetes and related metabolic syndromes.


cis-Clerodane-type furanoditerpenoids from Tinospora crispa.
Phytochemical and cytotoxicity investigations on organic solvent extracts of the aerial parts of Tinospora crispa have led to the isolation of 15 cis-clerodane-type furanoditerpenoids. Of these, nine
Oleanane Saponins and Glycerogalactolipids from the Leaves of Guapira graciliflora
Two new saponins, 3-O-[β-D-xylopyranosyl-(13)-β-D-galactopyranosyl-(13)-β-glucuronopyranosyl]oleanolic acid 28-O-β-D-glucopyranosyl ester (1) and the corresponding monodesmoside,
The hypoglycaemic and insulinotropic activity of Tinospora crispa: studies with human and rat islets and HIT-T15 B cells
These are the first studies to provide biochemical evidence which substantiates the traditional claims for an oral hypoglycaemic effect of Tinospora crispa, and which also show that the hypoglyCAemic effect is associated with increased insulin secretion.
Antidiabetic effects of Tinospora crispa in rats.
Studies on the Constituents of the Stems of Tinospora tuberculata, IV. Isolation and Structure Elucidation of the Five New Furanoid Diterpene Glycosides Borapetoside C–G
Five new furanoid diterpene glycosides, named borapetoside C (1), D (2), E (3), F (4), and G (5), were isolated from the stems of Tinospora tuberculata Beumee (Menispermaceae). The structures of 1–5
Insulin secretion and cyclooxygenase enzyme inhibition by cabernet sauvignon grape skin compounds.
This is the first report of beta-sitosterol-6'-linolenoyl-3-O-beta-D-glucopyranoside from grape skin and insulin secretion activities of compounds 4 and 5, which showed a dose-dependent insulin production in this assay.
Antihyperglycemic effect of a caffeamide derivative, KS370G, in normal and diabetic mice.
It was found that KS370G could stimulate the release of insulin in both normal and T2DM mice, and a dose of 1 mg per kg KS 370G could significantly attenuate the increase of plasma glucose induced by an intraperitoneal glucose challenge test in normal and diabetic mice.