Hypoglycemic agent YM440 suppresses hepatic glucose output via gluconeogenesis by reducing glucose-6-phosphatase activity in obese Zucker rats.

@article{Kurosaki2003HypoglycemicAY,
  title={Hypoglycemic agent YM440 suppresses hepatic glucose output via gluconeogenesis by reducing glucose-6-phosphatase activity in obese Zucker rats.},
  author={Eiji Kurosaki and Ryosuke Nakano and Kazuhiro Momose and Akiyoshi Shimaya and Takayuki Suzuki and Masayuki Shibasaki and Hisataka Shikama},
  journal={European journal of pharmacology},
  year={2003},
  volume={468 2},
  pages={151-8}
}
Using a glucose clamp, we had shown that YM440, (Z)-1,4-bis[4-[(3,5-dioxo-1,2,4-oxadiazolidin-2-yl)methyl]phenoxy]but-2-ene, reduced the increased hepatic glucose output in obese Zucker rats. We further examined effects of YM440 on 14C-incorporation from [14C]bicarbonate into blood glucose via gluconeogenesis, and on gluconeogenic enzymatic activities. Fed obese Zucker rats showed a 4-fold increase of 14C-incorporation into blood glucose compared to that in lean rats. Glucose-6-phosphatase and… CONTINUE READING

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