• Corpus ID: 26723500

Hypoglycemic Effect Of Button ( Agaricus Bisporus ) And Oyster ( Pleurotus Ostreatus ) Mushrooms On Streptozotocin Induced Diabetic Mice

@inproceedings{Shehata2010HypoglycemicEO,
  title={Hypoglycemic Effect Of Button ( Agaricus Bisporus ) And Oyster ( Pleurotus Ostreatus ) Mushrooms On Streptozotocin Induced Diabetic Mice},
  author={Yousef M. Shehata and Yousri Mostafa Hussein and Aaser M Abdelazim and Rasha L. Etewa and Mohamed H. Alhady},
  year={2010}
}

• Y. M. Shehata, Y. Hussein, +2 authors Mohamed H. Alhady
• Published 2010
• Medicine

In the present study, we examined the hypoglycemic effect of two species of edible mushrooms which are widely cultivated in Egypt. Fifty-six male Swiss mice of average weight 25±5 grams were used in the study. Mice were randomly divided into two main groups. Group A that served as control did not receive any treatment and group B was sterptozotocin (STZ)-induced diabetic group. The latter was divided into three subgroups, B1 diabetic–insulin treated, B2 diabetic–oyster and B3 diabetic–button agaricus. Blood glucose levels were routinely determined every week. After 30 and 60 days, mice from all groups were sacrificed. Blood samples and livers were collected for determination of hepatic glycogen, hepatic glucokinase activity and mRNA expression levels of GK. Our results revealed a significant hypoglycemic effect of the two species of mushrooms. There was a significant change in the hepatic glycogen content with a marked increase in the expression level of GK in mushroom feeding groups. We can conclude that Oyster and Button mushrooms have a potent hypoglycemic effect on diabetic mice which gives us a new prospect to face diabetes mellitus with high effect and low cost.