Hypoglycemia leads to age-related loss of vision.

  title={Hypoglycemia leads to age-related loss of vision.},
  author={Yumiko Umino and Drew Everhart and Eduardo C. Solessio and Karen Cusato and James C-H Pan and Trung Hai Nguyen and Erika T. Brown and R Hafler and Bridget Frio and Barry E. Knox and Gustav A. Engbretson and Mohammad Haeri and Liang Cui and Alan Scott Glenn and Maureen J. Charron and Robert B. Barlow},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={103 51},
The retina is among the most metabolically active tissues in the body, requiring a constant supply of blood glucose to sustain function. We assessed the impact of low blood glucose on the vision of C57BL/6J mice rendered hypoglycemic by a null mutation of the glucagon receptor gene, Gcgr. Metabolic stress from moderate hypoglycemia led to late-onset loss of retinal function in Gcgr(-/-) mice, loss of visual acuity, and eventual death of retinal cells. Retinal function measured by the… CONTINUE READING