Hypoglycemia activates orexin neurons and selectively increases hypothalamic orexin-B levels: responses inhibited by feeding and possibly mediated by the nucleus of the solitary tract.

@article{Cai2001HypoglycemiaAO,
  title={Hypoglycemia activates orexin neurons and selectively increases hypothalamic orexin-B levels: responses inhibited by feeding and possibly mediated by the nucleus of the solitary tract.},
  author={Xue J. Cai and Mark Evans and Carolyn A Lister and Ronald A. Leslie and Jonathan R.S Arch and Shelagh Wilson and G. Ishmael Williams},
  journal={Diabetes},
  year={2001},
  volume={50 1},
  pages={105-12}
}
Orexins are novel appetite-stimulating peptides expressed in the lateral hypothalamic area (LHA), and their expression is stimulated by hypoglycemia in fasted rats. We investigated activation of orexin and other neurons during insulin-induced hypoglycemia using the immediate early gene product Fos. Insulin (50 U/kg) lowered plasma glucose by >50% after 5 h and stimulated feeding sixfold compared with saline-injected controls. Hypoglycemic rats allowed to feed and normoglycemic controls both… CONTINUE READING
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