Hypofractionated boost with high-dose-rate brachytherapy and open magnetic resonance imaging-guided implants for locally aggressive prostate cancer: a sequential dose-escalation pilot study.

@article{Ares2009HypofractionatedBW,
  title={Hypofractionated boost with high-dose-rate brachytherapy and open magnetic resonance imaging-guided implants for locally aggressive prostate cancer: a sequential dose-escalation pilot study.},
  author={Carmen Ares and Youri Popowski and Sandro Pampallona and Philippe Nouet and Giovanna Dipasquale and Sabine Bieri and Orhan Ozsoy and Michel Rouzaud and Haleem Khan and Raymond Miralbell},
  journal={International journal of radiation oncology, biology, physics},
  year={2009},
  volume={75 3},
  pages={656-63}
}
PURPOSE To evaluate the feasibility, tolerance, and preliminary outcome of an open MRI-guided prostate partial-volume high-dose-rate brachytherapy (HDR-BT) schedule in a group of selected patients with nonmetastatic, locally aggressive prostatic tumors. METHODS AND MATERIALS After conventional fractionated three-dimensional conformal external radiotherapy to 64-64.4 Gy, 77 patients with nonmetastatic, locally aggressive (e.g., perineural invasion and/or Gleason score 8-10) prostate cancer… CONTINUE READING

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