Hypofibrinolytic state in HIV-1-infected patients treated with protease inhibitor-containing highly active antiretroviral therapy.

@article{Koppel2002HypofibrinolyticSI,
  title={Hypofibrinolytic state in HIV-1-infected patients treated with protease inhibitor-containing highly active antiretroviral therapy.},
  author={Kristina Koppel and G{\"o}ran A Bratt and Sam Schulman and H{\aa}kan Bylund and Eric Sandstr{\"o}m},
  journal={Journal of acquired immune deficiency syndromes},
  year={2002},
  volume={29 5},
  pages={441-9}
}
Decreased insulin sensitivity, hyperlipidemia, and body fat changes are considered as risk factors for coronary heart disease (CHD). A clustering of such factors (metabolic syndrome [MSDR]) exponentially increases the risk. Impaired fibrinolysis and increased coagulation are additional independent risk factors for CHD. We studied the effects of protease inhibitor (PI)-containing highly active antiretroviral therapy (HAART) on metabolic and hemostatic parameters in 363 HIV-infected individuals… CONTINUE READING
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