Hypofibrinolysis in type 2 diabetes: the role of the inflammatory pathway and complement C3

@article{Hess2014HypofibrinolysisIT,
  title={Hypofibrinolysis in type 2 diabetes: the role of the inflammatory pathway and complement C3},
  author={Katharina Hess and Saad Alzahrani and Jackie F. Price and Mark W. J. Strachan and Natalie Oxley and Rhodri J King and Tobias Gamlen and Verena Schroeder and Paul David Baxter and Ramzi A. Ajjan},
  journal={Diabetologia},
  year={2014},
  volume={57},
  pages={1737-1741}
}
Plasminogen activator inhibitor-1 (PAI-1) has been regarded as the main antifibrinolytic protein in diabetes, but recent work indicates that complement C3 (C3), an inflammatory protein, directly compromises fibrinolysis in type 1 diabetes. The aim of the current project was to investigate associations between C3 and fibrinolysis in a large cohort of individuals with type 2 diabetes. Plasma levels of C3, C-reactive protein (CRP), PAI-1 and fibrinogen were analysed by ELISA in 837 patients… CONTINUE READING