Hypocretins (orexins): The ultimate translational neuropeptides

@article{Jacobson2022HypocretinsT,
  title={Hypocretins (orexins): The ultimate translational neuropeptides},
  author={Laura H. Jacobson and Daniel Hoyer and Luis de Lecea},
  journal={Journal of Internal Medicine},
  year={2022},
  volume={291},
  pages={533 - 556}
}
The hypocretins (Hcrts), also known as orexins, are two neuropeptides produced exclusively in the lateral hypothalamus. They act on two specific receptors that are widely distributed across the brain and involved in a myriad of neurophysiological functions that include sleep, arousal, feeding, reward, fear, anxiety and cognition. Hcrt cell loss in humans leads to narcolepsy with cataplexy (narcolepsy type 1), a disorder characterized by intrusions of sleep into wakefulness, demonstrating that… 

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TLDR
The orexin/hypocretin receptor coordinates, now available to the broader academic and drug discovery community, will facilitate rational design of new therapeutics that modulate orexIn/ hypocretin signaling in humans.

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TLDR
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