Hypocretin receptor 1 knockdown in the ventral tegmental area attenuates mesolimbic dopamine signaling and reduces motivation for cocaine.

@article{Bernstein2017HypocretinR1,
  title={Hypocretin receptor 1 knockdown in the ventral tegmental area attenuates mesolimbic dopamine signaling and reduces motivation for cocaine.},
  author={David L. Bernstein and Preeti S Badve and Jessica R Barson and Caroline E Bass and Rodrigo A Espa{\~n}a},
  journal={Addiction biology},
  year={2017}
}
The hypocretin receptor 1 (HCRTr1) is a critical participant in the regulation of motivated behavior. Previous observations demonstrate that acute pharmacological blockade of HCRTr1 disrupts dopamine (DA) signaling and the motivation for cocaine when delivered systemically or directly into the ventral tegmental area (VTA). To further examine the involvement… CONTINUE READING