Hypocretin in cerebrospinal fluid is positively correlated with Tau and pTau.


It has been suggested that sleep-wake regulation as well as hypocretins play a role in the pathophysiology of Alzheimer's disease. We analyzed Aβ40, Aβ42, Tau protein, phosphorylated Tau (pTau) protein as well as hypocretin-1 concentrations in the CSF of a detection sample of 10 patients with Alzheimer's disease (AD) as well as 10 age- and gender-matched… (More)
DOI: 10.1016/j.neulet.2013.12.036


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