Hypocretin-1 Deficiency in a Girl With ROHHAD Syndrome

@article{Dhondt2013Hypocretin1DI,
  title={Hypocretin-1 Deficiency in a Girl With ROHHAD Syndrome},
  author={Karlien Dhondt and Patrick Verloo and Helene Verhelst and Rudy Van Coster and Sebastiaan Overeem},
  journal={Pediatrics},
  year={2013},
  volume={132},
  pages={e788 - e792}
}
Rapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation (ROHHAD) is a rare and complex pediatric syndrome, essentially caused by dysfunction of 3 vital systems regulating endocrine, respiratory, and autonomic nervous system functioning. The clinical spectrum of ROHHAD is broad, but sleep/wake disorders have received relatively little attention so far, although the central hypothalamic dysfunction would make the occurrence of sleep symptoms likely. In this… 
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