Hypocretin-1 (orexin A) deficiency in acute traumatic brain injury.

  title={Hypocretin-1 (orexin A) deficiency in acute traumatic brain injury.},
  author={Christian R. Baumann and Reto Stocker and H. G. Imhof and Otmar L Trentz and Martin Hersberger and Emmanuel Mignot and Claudio Bassetti},
  volume={65 1},
Hypocretin-1 is involved in the regulation of the sleep-wake cycle. The authors prospectively assessed CSF hypocretin-1 levels in 44 consecutive patients with acute traumatic brain injury (TBI). Compared with controls, hypocretin-1 levels were abnormally lower in 95% of patients with moderate to severe TBI and in 97% of patients with posttraumatic brain CT changes. Hypocretin-1 deficiency after TBI may reflect hypothalamic damage and be linked with the frequent development of posttraumatic… CONTINUE READING