Hypocretin/orexin suppresses corticotroph responsiveness in vitro.

  title={Hypocretin/orexin suppresses corticotroph responsiveness in vitro.},
  author={Willis K Samson and Meghan M. Taylor},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  volume={281 4},
The hypocretin/orexins (Hcrts/ORXs) are peptides produced in neurons in the lateral hypothalamic area that project to neuroendocrine centers in the hypothalamus. Hcrt/ORX receptors are present in the hypothalamus and anterior pituitary gland. We examined the possibility that the Hcrts/ORXs, which we have demonstrated previously to act in the brain to stimulate sympathetic function, could alter stress hormone secretion by a direct pituitary action. In vitro studies revealed a dose-related… CONTINUE READING


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