Hypocretin/orexin-containing neurons are produced in one sharp peak in the developing ventral diencephalon.

@article{Amiot2005HypocretinorexincontainingNA,
  title={Hypocretin/orexin-containing neurons are produced in one sharp peak in the developing ventral diencephalon.},
  author={Clotilde Amiot and Fr{\'e}d{\'e}ric Brischoux and Claude Colard and Annie La Roche and Dominique Fellmann and P. Y. Risold},
  journal={The European journal of neuroscience},
  year={2005},
  volume={22 2},
  pages={531-4}
}
The birth date of hypocretin-containing neurons was analysed using the bromodeoxyuridine method in the rat. The results indicate that these neurons are generated between embryonic days 11 (E11) and E14, with a sharp peak on E12. This spatiotemporal pattern of genesis contrasts with that of the co-distributed neurons producing the melanin-concentrating hormone in the lateral hypothalamic area, which have been described as generated in one large peak from E10 to E16. These observations may be… CONTINUE READING