Hypocretin/Orexin Signaling in the Hypothalamic Paraventricular Nucleus is Essential for the Expression of Nicotine Withdrawal

@article{PlazaZabala2012HypocretinOrexinSI,
  title={Hypocretin/Orexin Signaling in the Hypothalamic Paraventricular Nucleus is Essential for the Expression of Nicotine Withdrawal},
  author={Ainhoa Plaza-Zabala and {\'A}frica Flores and Rafael Maldonado and Fernando Berrendero},
  journal={Biological Psychiatry},
  year={2012},
  volume={71},
  pages={214-223}
}
BACKGROUND Hypocretin (orexin) signaling is involved in drug addiction. In this study, we investigated the role of these hypothalamic neuropeptides in nicotine withdrawal by using behavioral and neuroanatomical approaches. METHODS Nicotine withdrawal syndrome was precipitated by mecamylamine (2 mg/kg, subcutaneous) in C57BL/6J nicotine-dependent mice (25 mg/kg/day for 14 days) pretreated with the hypocretin receptor 1 (Hcrtr-1) antagonist SB334867 (5 and 10 mg/kg, intraperitoneal), the… CONTINUE READING

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