Hypocrellin D, a Cytotoxic Fungal Pigment from Fruiting Bodies of the Ascomycete Shiraia bambusicola

  title={Hypocrellin D, a Cytotoxic Fungal Pigment from Fruiting Bodies of the Ascomycete Shiraia bambusicola},
  author={Li-Zhen Fang and Chen Qing and Hong-jun Shao and Yi-Dong Yang and Ze-Jun Dong and Fei Wang and Wei Zhao and Wan-Qiu Yang and Jikai Liu},
  journal={The Journal of Antibiotics},
A fungal pigment, hypocrellin D (1), together with three known perylenequinone derivatives hypocrellin A (2), B (3) and C (4), was isolated from the fruiting bodies of Shiraia bambusicola. Its structure was elucidated on the basis of spectral data including 2D NMR experiments. Hypocrellin D (1) significantly inhibited the growth of tumor cell lines Bel-7721, A-549 and Anip-973 with IC50 values of 1.8, 8.8, 38.4 μg/ml, respectively. 


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