Hypochondroplastic dwarfism in the Irish setter.

  title={Hypochondroplastic dwarfism in the Irish setter.},
  author={I. Hanssen and G. Falck and A. Grammeltvedt and E. Haug and C. Isaksen},
  journal={The Journal of small animal practice},
  volume={39 1},
Two test matings in the irish setter were performed, and genetic, clinical, morphometric, radiographic, bone histological and plasma and urine biochemical features of dwarfism were studied. All offspring were phenotypically normal at birth and weaning, but at the age of 2.5 to 4 months the longitudinal growth of the spine and leg bones was retarded in the dwarfs compared with the normal littermates. Most dwarfs performed well, even in the field. Radiographic and histological evaluations… Expand
Here we present the radiographic findings of limb and spine in a 15-month-old female Bichon with pseudoachondroplasia (PSACH). PSACH is a rare form of osteochondrodysplasia, the main clinicalExpand
Histopathologic study of long-bone growth plates confirms the basset hound as an osteochondrodysplastic breed.
The basset hound can be defined only as a breed having osteochondrodysplasia due to a primary cartilage problem in the growth plate, and by this method the breed is considered a breed with a disproportionate prevalence of dwarfism. Expand
Short and sweet: foreleg abnormalities in Havanese and the role of the FGF4 retrogene
The results indicate that FGF4RG-associated chondrodystrophy may contribute to the shortened forelegs found in some Havanese and that both the wild type and mutant allele segregate in the breed. Expand
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This review is focussed on the use of novel tools now available for comparative molecular genetic studies of skeletal dysplasias in the dog. Expand
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This thesis work has provided insights into the molecular genetic background of three autosomal recessive diseases that affect specific dog breeds and revealed three new disease-linked genes in dogs, which may be associated to similar disorders in other species. Expand
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An inherited enchondrodystrophy in the English Pointer dog. A new disease
The genetics are compatible with a homozygous recessive mode of inheritance and the clinical, radiological, pathological and genetic features of an inherited dwarfism in the English Pointer are described. Expand
Short-limbed dwarfism and ocular defects in the Samoyed dog.
A syndrome of short-limbed dwarfism and ocular defects was found in Samoyed dogs and family studies and limited breeding experiments were consistent with an autosomal recessive mode of inheritance. Expand
Pseudoachondroplastic dysplasia in miniature poodles: clinical, radiologic, and pathologic features.
The clinical, radiologic, and pathologic features of pseudoachondroplastic dysplasia were studied in 13 affected Miniature Poodles, finding that general health appears normal, except for restricted locomotion due to secondary arthritis and difficult breathing in dogs with a deformed thorax. Expand
Clinical, radiographic, pathologic, and genetic features of osteochondrodysplasia in Scottish deerhounds.
Skeletal changes characterized by abnormalities in long bones and vertebrae and irregular and delayed epiphyseal ossification were most noticeable in younger pups; in older pups, bony deformities became more prominent and osteopenia and severe deformities were seen. Expand
Chondrodysplasia in the Norwegian Elkhound.
Dwarfism in the Norwegian Elkhound occurred as a result of a generalized disturbance in endochondral ossification, which revealed poor differentiation into territorial and interterritorial zones. Expand
Retinal dysplasia associated with skeletal abnormalities in Labrador Retrievers.
Ocular changes were characterized by retinal dysplasia, with retinal detachment and cataract formation, and skeletal changes included retarded growth in the radius, ulna, and tibia. Expand
Animal models of dwarfism.
  • R. Sande, S. Bingel
  • Medicine
  • The Veterinary clinics of North America. Small animal practice
  • 1983
Achondroplasia in a litter of pups.