Hypocholesterolemic actions of atorvastatin are associated with alterations on hepatic cholesterol metabolism and lipoprotein composition in the guinea pig.

@article{Conde1996HypocholesterolemicAO,
  title={Hypocholesterolemic actions of atorvastatin are associated with alterations on hepatic cholesterol metabolism and lipoprotein composition in the guinea pig.},
  author={Karin Conde and Marcela de Jes{\'u}s Vergara-Jim{\'e}nez and Brian R. Krause and R. S. Newton and Maria Luz Fernandez},
  journal={Journal of lipid research},
  year={1996},
  volume={37 11},
  pages={2372-82}
}
Guinea pigs were fed 15% (w/W) fat, high in lauric and myristic acids, a diet known to produce hypercholesterolemia in these animals. The diet was given alone or in combination with four doses of atorvastatin equivalent to 1, 3, 10, and 20 mg/kg per day. Atorvastatin reduced plasma LDL cholesterol concentrations by 46, 50, 53, and 70%, respectively (P < 0.001). Plasma apoB concentrations were reduced by atorvastatin (P < 0.001) and compositional changes occurred in VLDL and LDL with reductions… CONTINUE READING