Hypochlorous acid-mediated mitochondrial dysfunction and apoptosis in human hepatoma HepG2 and human fetal liver cells: role of mitochondrial permeability transition.

@article{Whiteman2005HypochlorousAM,
  title={Hypochlorous acid-mediated mitochondrial dysfunction and apoptosis in human hepatoma HepG2 and human fetal liver cells: role of mitochondrial permeability transition.},
  author={Matthew Whiteman and Peter Rose and Jia Ling Siau and Nam Sang Cheung and Gek San Tan and Barry Halliwell and Jeffrey Armstrong},
  journal={Free radical biology & medicine},
  year={2005},
  volume={38 12},
  pages={1571-84}
}
Liver cirrhosis is often preceded by overt signs of hepatitis, including parenchymal cell inflammation and infiltration of polymorphonuclear (PMN) leukocytes. Activated PMNs release both reactive oxygen species and reactive halogen species, including hypochlorous acid (HOCl), which are known to be significantly cytotoxic due to their oxidizing potential. Because the role of mitochondria in the hepatotoxicity attributed to HOCl has not been elucidated, we investigated the effects of HOCl on… CONTINUE READING